Endocrine Abstracts

Background: Omission of steroids and unsafe steroid prescription in Adrenal insufficiency (AI) patients during intercurrent illness or surgery is unfortunately common, and can lead to adrenal crisis and potentially death. Anna Mitchell et al, New Castle-upon-Tyne have demonstrated potential use of electronic automation with steroid alerts to minimise human error for ensuring patient safety.Objectives: 1. Similar use of artificial intelligence wa...

Background: Radiotherapy is a third line treatment in Acromegaly. Pituitary radiotherapy (RT) is known to have cardiovascular complications (MI/IHD, CCF & CVA) due to radiation effects on normal pituitary and surrounding structures over and above the excess Growth hormone risk on metabolism (1).Objective: To compare RT vs non-RT treated Acromegaly cohorts’ cardiovascular (CV) outcomes in unselected consecutive Acromegaly patients.<p class="a...

Introduction: Glioblastoma, an aggressive intracranial tumour usually is a solitary lesion and not commonly located in the sella turcica. Panhypopituitarism due to multicentric glioblastoma can present with a challenging clinical picture masking or delaying the underlying diagnosis. Case presentation: 58 year old female presented with marked behavioural change, reduced appetite, nausea, polyuria & increased thirst over 4-6 weeks precipitating into an...

Background: Adrenal crisis is a life threatening emergency with an incidence of 5–10 adrenal crises/100 patient-years with mortality around 0.5/100 patient-years.Objective: Audit of inpatient adrenal crisis management was undertaken in line with Society for Endocrinology (SFE) guidance 2016 (Trust audit No:9763).Methods: Retrospective evaluation of electronic and paper case records of 2 years (January 2017–December 2018)....

Background: British Association of Thyroid and Endocrine Surgeons defines post-operative hypocalcaemia as adjusted calcium of < 2.0 mmol/l; ‘late hypocalcaemia’ as the ongoing requirement for calcium/Vitamin D supplements at 6 months; permanent post-surgical hypoparathyroidism (PSHP) at 12 months. The incidence rates of late hypocalcaemia are 6.5–12.1% and PSHP is 0.9%–4.5%.Objective: To evaluate PSHP incidence rate in total thyro...

Background: Premature Ovarian Insufficiency (POI) is characterised by oligo-/amenorrhoea with elevated gonadotropins and low oestradiol before the age of 40 years.Objective: To evaluate management of non-Turner POI patients in line with European Society of Human Reproduction and Embryology (ESHRE) guidance (1)Methods: Retrospective evaluation of electronic and paper case records.Results: Over 23-year period (...

Thyroid hormones are important regulators of fetal growth, although their mechanism of action remains unclear. In the sheep fetus, thyroid hormone deficiency increases plasma insulin and leptin concentrations. This study investigated the effects of hypothyroidism on perirenal adipose tissue (PAT) development and adipose insulin signalling pathways in fetal sheep.All procedures were performed under the UK Animals (Scientific Procedures) Act 1986. In 10 tw...

Background: TS, resulting from partial or complete loss of an X-chromosome, is a rare diagnosis1. In addition to its well-described phenotypic features2, a number of multi-systemic conditions may develop over the lifespan of a Turner female that require long-term surveillance which is challenging to deliver in today’s ‘specialised’ services NHS.Aim: To evaluate UHL service provision against the only guidelines for the...

Background: Structured education programmes (SEP) have proved effective in changing illness perception and increasing physical activity (PA) in those with or at risk of diabetes. The SUCCESS–RCT was designed to test such a programme in women with polycystic ovary syndrome (PCOS).Methods: This was a single centre, randomised controlled trial in overweight and obese women with PCOS aimed at increasing their walking activity by 2000 steps/day after 12 ...

Thyroid hormones are important regulators of fetal growth, although their mechanism of action remains unclear. This study investigated the effect of hypothyroidism on pancreatic β-cell development in foetal sheep.All procedures were carried out under the UK Animals (Scientific Procedures) Act 1986. Under general anaesthesia between 105 and 110 days of gestation (days; term ~145 days), one twin fetus was thyroidectomised (TX), while the other was sha...